The allogeneic effect in inbred mice: V. Analysis of B cell immunoglobulin classes influenced by non-specific and carrier-specific T cell stimuli

Abstract

The studies presented here show that the allogeneic effect on adoptive secondary responses to homologous and heterologous conjugates affects the plaque-forming cell response of immunoglobulin classes IgM, IgG, IgG 1, IgG 2a + 2b and IgA. We have demonstrated that the increase in PFC resulting from the allogeneic effect varies among the immunoglobulin classes analyzed, most probably reflecting the relative frequencies of precursor B cells in a particular primed cell population, and not a preferential stimulation of one class of B lymphocytes. A comparison of the allogeneic effect and the syngeneic cooperative response between carrier-primed T cells and hapten-specific B cells showed parallel responses of DNP-specinc PFC of all classes studied.