Abstract
The kinetics of the hydrolysis of methyl 4-hydroxy and methyl 4-methoxytetrahydrofuran-2-carboxylates has been studied. It is shown that saponification assisted by an intramolecular neighbouring hydroxyl group has higher enthalpy of activation and larger entropy of activation. These results suggest that the saponification of esters in aqueous medium is an electrophilic (H 2O)-nucleophilic (OH) catalytic reaction.
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