Abstract
BackgroundLimited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the Alberta Moving Beyond Breast Cancer (AMBER) Study, a prospective cohort study designed specifically to examine the role of physical activity and health-related fitness in breast cancer survivorship from the time of diagnosis and for the balance of life. The AMBER Study will examine the role of physical activity and health-related fitness in facilitating treatment completion, alleviating treatment side effects, hastening recovery after treatments, improving long term quality of life, and reducing the risks of disease recurrence, other chronic diseases, and premature death.Methods/DesignThe AMBER Study will enroll 1500 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a 5 year period. Assessments will be made at baseline (within 90 days of surgery), 1 year, and 3 years consisting of objective and self-reported measurements of physical activity, health-related fitness, blood collection, lymphedema, patient-reported outcomes, and determinants of physical activity. A final assessment at 5 years will measure patient-reported data only. The cohort members will be followed for an additional 5 years for disease outcomes.DiscussionThe AMBER cohort will answer key questions related to physical activity and health-related fitness in breast cancer survivors including: (1) the independent and interactive associations of physical activity and health-related fitness with disease outcomes (e.g., recurrence, breast cancer-specific mortality, overall survival), treatment completion rates, symptoms and side effects (e.g., pain, lymphedema, fatigue, neuropathy), quality of life, and psychosocial functioning (e.g., anxiety, depression, self-esteem, happiness), (2) the determinants of physical activity and health-related fitness including demographic, medical, social cognitive, and environmental variables, (3) the mediators of any observed associations between physical activity, health-related fitness, and health outcomes including biological, functional, and psychosocial, and (4) the moderators of any observed associations including demographic, medical, and biological/disease factors. Taken together, these data will provide a comprehensive inquiry into the outcomes, determinants, mechanisms, and moderators of physical activity and health-related fitness in breast cancer survivors.
Highlights
Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors
The Alberta Moving Beyond Breast Cancer (AMBER) cohort will answer key questions related to physical activity and health-related fitness in breast cancer survivors including: (1) the independent and interactive associations of physical activity and health-related fitness with disease outcomes, treatment completion rates, symptoms and side effects, quality of life, and psychosocial functioning, (2) the determinants of physical activity and health-related fitness including demographic, medical, social cognitive, and environmental variables, (3) the mediators of any observed associations between physical activity, health-related fitness, and health outcomes including biological, functional, and psychosocial, and (4) the moderators of any observed associations including demographic, medical, and biological/disease factors
These data will provide a comprehensive inquiry into the outcomes, determinants, mechanisms, and moderators of physical activity and health-related fitness in breast cancer survivors
Summary
The primary focus of the AMBER Study will be to identify the independent and interactive associations of PA and HRF with disease outcomes (e.g., recurrence, breast cancerspecific mortality, overall survival). Health-related fitness, and biologic mechanisms The primary aim of this project is to examine the mechanisms that may explain any associations between selfreported and objective PA (including sedentary behavior), HRF (including body composition), and disease outcomes in breast cancer survivors (including recurrence-free interval, breast cancer mortality, and overall survival). Breast cancer survivors experiencing treatment related effects such as lymphedema, upper limb morbidity and peripheral neuropathy, may have unique challenges that impact their PA, HRF, and PROs. Determinants of physical activity and health-related fitness The aim of this study is to develop a comprehensive understanding of the determinants of PA in breast cancer survivors across the survivorship continuum.
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