Abstract
First introduced in August 2014, the Airyscan detector from ZEISS represents a new detector concept for laser scanning microscopy (LSM) that enables a simultaneous resolution and signal-to-noise ratio (SNR) increase over traditional LSM imaging. The Airyscan detector innovation replaces the conventional LSM detector and pinhole scheme for an array of 32 sensitive GaAsP detector elements placed in the pinhole plane to generate an optical section. The new detection geometry allows for the collection of the spatial distribution of light originating from every point of a microscopic fluorescent object at the pinhole allowing access to higher frequency information and while additionally collecting more light for ultra-efficient imaging. In May 2015, the fast mode innovation for Airyscan combines illumination shaping with pinhole-plane imaging that enhances acquisition speeds by four times while simultaneously increasing SNR and resolution overcoming the traditional compromises of LSM imaging.
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