Abstract
AbstractGlybornuride is an oral hypoglucaemiant whose solubility in water is considerably increased by solid dispersion in P.E.G. 6000. The present article reports the effect of storage at 25 2 C on such dispersion. After 1 year slight alterations in DSC thermograms and X-Ray diffraction spectra are apparent and in studies of dissolution kinetics there is a significant reduction in the percentage of glybornuride dissolved after 6 and 12 months, but glucaemia levels in rabbits recorded after 6, 9 and 12 months do not differ significantly from those obtained with the freshly prepared dispersion
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