Abstract
Two thirds hepatectomy was carried out on female Wistar rats of 24–25 months of age. The regenerated livers of 5 animals each were investigated 1, 5, 10, 20 days subsequent to hepatectomy using electron microscopic morphometry. The results show that liver cells of old animals display the same degree of aging even after regeneration, i.e. the surface area and surface density of the rough endoplasmic reticulum remain reduced to the same extent, as observed in the old control group. The regeneration caused a rejuvenation only of the mitochondria showing surface area and surface density of inner membrane + cristae corresponding to the values obtained in the young (1-month-old) animals. The results seem to support the idea that the accumulation of somatic mutations such as a strong reduction of the protein synthetic apparatus, may play an important role in the aging process.
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