Abstract
Gerontology & Geriatrics studies The Aging Brain: Recent Research and Concepts Vinod Nikhra* Hindu Rao Hospital, India *Corresponding author: Vinod Nikhra, Senior Chief Medical Officer and Teaching faculty, Hindu Rao Hospital, A public sector thousand-bed multi specialty Hospital, India Submission: October 23, 2017; Published: December 05, 2017 DOI: 10.31031/GGS.2017.01.000511 ISSN : 2578-0093Volume1 Issue3
Highlights
The aging of the brain is due to pathophysiological changes over the period of individual lifespan
Infective and inflammatory posed to the humanbeing lead to subcellular, cellular and tissue abnormalities resulting in neuronal adaptation, senescence and degeneration culminating into the complex phenomenon of aging of brain (Figure 1)
The dopamine deficiency with age is responsible for many neurological symptoms that increase in frequency with age, such
Summary
The aging of the brain is due to pathophysiological changes over the period of individual lifespan. The brain shows a decline in cognitive function and alterations in gene expression This modulation in gene expression may be due to oxidative DNA damage at promoter regions in the genome. This has been endorsed by the research in animal models, which documents distinct changes in the expression of genes at the neuronal level with aging [42]. MDA is a highly reactive compound and a marker for oxidative stress and a measure of free radical activity It has been reported in animal studies that the young 4-day-old rats have about 3,000 single-strand breaks and 156 double-strand breaks per neuron, whereas in rats older than 2 years the level of damage is increased to about 7,400 singlestrand breaks and 600 double-strand breaks per neuron [44]. Certain other transmitters are used in fewer synapses, albeit they are important
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