The agaricus bisporus mushroom extract modulates liver fibrosis progression, oxidative stress and inflammation in vitro and in Ldlr-KO mice models

Abstract

Rationale: Liver fibrosis can be caused by non-alcoholic steatohepatitis, among other conditions, being considered a growing problem for public health worldwide. In order to investigate new strategies to attenuate liver fibrosis progression, we analyzed the effects of a nontoxic water-soluble extract of the edible mushroom Agaricus bisporus (AB) as a potential inhibitor of fibrosis progression.