The Affection Of Different Weeks Hiit And Moderate Intensity Aerobic Exercise For Cardiac Muscle’S Ampk And Pgc1 α Of Rats

Abstract

PURPOSE: Through the research about the affection of different weeks HIIT and moderate-intensity aerobic training on cardiac muscle oxidative ability and cardiorespiratory fitness to determine the effective load of HIIT and MICT to Improve the cardiorespiratory fitness. METHODS: 120 6-week-old male Wistar rats were randomly divided into 4 groups (N=30): 2 week Group (C), 4 week Group (D), 6 week Group (E), 10 week Group (F). Each group contains a control, moderate-intensity training with HIIT three teams, 10 rats in each group. Rats in the control group didn't exercise , the training program of exercise group rats were depended on the Results of the maximal oxygen uptake test. 50 minutes exercise per day and 5 times per week. Rats in each group after the prescribed number of weeks were collected cardiac muscle. Protein levels of AMPK and PGC-1α were detected by Western blotting. SPSS17.0 for data analysis. RESULTS: 1. 2 weeks and 10 weeks of HIIT group on improving of rat cardiac muscle oxidative capacity and cardiovascular fitness has a significant impact (P<0.05);2. HIIT on aerobic capacity in rats at 10 weeks improved most significantly (P<0.05), MICT on aerobic capacity of rats had no significant effect in 10 weeks; 3.The change of AMPK and PGC-1αand Vo2max in the HIIT group are more consistent than its in the MICT group. CONCLUSION: 1. HIIT is more effective than Moderate-intensity continuous training in the way to improve aerobic capacity; 2. Effect of Long-term HIIT can be more pronounced in respect of enhancing aerobic capacity; 3. HIIT can promote cardiac muscle aerobic capacity through AMPK/PGC-1-α Signaling Pathway.