Abstract
The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.
Highlights
Arynes or benzynes are the highly reactive species derived from an aromatic ring by removal of two ortho substituents [1, 2]
The arynes react as electrophiles and in some pericyclic reactions because of their low-lying LUMO result
Their utility in total synthesis has been proved to date
Summary
Arynes or benzynes are the highly reactive species derived from an aromatic ring by removal of two ortho substituents [1, 2]. The uses and applications of aryne precursors as the efficient reactivity in the organic synthesis reactions have attracted the significant attention since the 1950s. Md. Ashraful Alam et al.: The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review useful building blocks as well as core structures in biologically active natural products [12]. Plenty of meticulous new applications of aryne reactions have been continuously reported by synthetic chemists [16].
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