Abstract
Along with people living horizontal increases continuously, obesity has become a global health problem that has reached its epidemic level not only in the Western countries, but also in developing countries. Accumulated evidence point out a negative impact of obesity on male reproduction. Obesity negatively affects male reproductive potential not only by reducing sperm quality, but in particular it alters the physical and molecular structure of germ cells in the testes, increases oxidative stress inside seminiferous tubules and ultimately affects the maturity and function of sperm cells. Interestingly, adipose tissue also exerts a positive effect on male reproduction. Appropriate lipid distribution appears to be indispensable for production of mature, functional sperm, according to a very new study in human and genetically engineering mice.
Highlights
Along with people living horizontal increases continuously, obesity has become a global health problem that has reached its epidemic level in the Western countries, and in developing countries
Seipin is highly expressed in human brain, testis, and adipose tissue
Cui X et al unexpectedly made the surprising observation that seipin-deficient mice model BSCL2 with marked lipodystrophy and exhibit complete male infertility, revealing a potential pivotal role of seipin during mammalian spermatogenesis. They studied a male patient from a family affected by lipodystrophy, hoping to establish a relationship between lipodystrophy and male fertility
Summary
Along with people living horizontal increases continuously, obesity has become a global health problem that has reached its epidemic level in the Western countries, and in developing countries. The Adipose Tissue: The New Positive Controller of Male Fertility? Accumulated evidence point out a negative impact of obesity on male reproduction.
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