Abstract
Titanium oxide (Ti-O) films with different thicknesses were deposited on 316 L stainless steel and bare metal stents with the filtered cathodic vacuum arc technique. The adhesion of the Ti-O films with different thicknesses on the 316 L stainless steel sheets was studied by the tension test. The adhesion, corrosion resistance, and fatigue behavior of the Ti-O film-modified stents were then evaluated. The results show that a 25-nm-thick Ti-O film on stainless steel is tightly adhered on the stainless steel after 40% relative elongation of the steel substrate. The 25-nm-thick Ti-O film-modified bare metal stent has sufficient mechanical stability, good corrosion resistance, and can withstand 380 million cycles of pulsatile fatigue testing without film destruction and delamination. A clinical trial of the bilayer drug eluting stent (DES) with a titanium oxide base layer and an anti-proliferative sirolimus top layer shows that our DES tends to reduce the incidence of late thrombosis.
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