Abstract
BackgroundBreast cancer is the most commonly diagnosed malignancy in women worldwide. Women with dense breast tend to have 15–25% lifetime risk of breast cancer due to decrease of mammographic sensitivity. Automated breast ultrasound (ABUS) is a new promising tool for detection of breast lesions masked by dense glandular tissue at mammography.ResultsThe sensitivity of digital mammography in detecting breast lesions was 60.7%, specificity 91.6%, PPV 85%, NPV 75%, and accuracy 78%. The sensitivity of ABUS in detecting breast lesions was 92.86%, specificity 77.78%, PPV 76.47%, NPV 93.33%, and accuracy 84.38%. The sensitivity of handheld ultrasound (HHUS) in detecting breast lesions was 89.29%, specificity 88.89%, PPV 86.21%, NPV 91.43%, and accuracy 89.06%.ConclusionThe sensitivity of ABUS in detecting breast lesions was much higher than mammography in dense breast while the digital mammography (DM) had higher specificity. So, implementation of both DM and ABUS to get benefit of DM specificity as well as ABUS sensitivity were highly recommended.
Highlights
Breast cancer is the most commonly diagnosed malignancy in women worldwide
Aim of work The aim of this study was to assess the ability of Automated breast ultrasound (ABUS) to detect mammographically occult breast lesions at dense breasts, assessing the diagnostic parameters of ABUS compared to digital mammography as well as handheld US (HHUS) in detection of breast lesions in dense breast
Each examination was evaluated regarding the following criteria according to the 5th edition of BIRADS lexicon
Summary
Breast cancer is the most commonly diagnosed malignancy in women worldwide. Women with dense breast tend to have 15–25% lifetime risk of breast cancer due to decrease of mammographic sensitivity. Automated breast ultrasound (ABUS) is a new promising tool for detection of breast lesions masked by dense glandular tissue at mammography. Breast cancer is the leading cause of cancer-related death among females worldwide [1]. Detection of breast cancer improves outcomes, i.e., survival is relatively good when these cancers are diagnosed at an early stage [2]. A recent study showed 43% number reduction among women participating in a national screening program [3]. Mammography is an effective randomized controlled trial-proven method for reducing mortality due to breast cancer [4]. The sensitivity of mammography depends on breast density. Studies on women with dense breasts have demonstrated a sensitivity of less than 50% [5]
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