The adaptation mechanisms of liver in combined pathologies

Abstract

The great potential of liver restoration has been described in different liver pathologies. There are various forms of liver diseases. Hence, comparative study of regenerative processes in different pathologies is especially significant for drawing out of modern methods of regenerative therapy.Earlier we have demonstrated that the reparative multiple growth of genome in some population of destructive liver cells occurs after bilateral adrenalectomy. In such conditions the resection of liver initiates a series of quick cell divisions (early mitoses) in the population of hepatocytes and provides partial repairing of liver functional activity. Bile duct ligation within 4 days also initiates the accumulation of polyplody cells in liver for repairing its functional activity. It is significant that at the same time the hepatocyte mitotic activity in cholestatic liver reaches the its maximal value.The aim of the present work was to study the adaptation mechanisms of liver in combined pathologies (bilateral adrenalectomy and cholestasis).The investigations were carried out on 50 adult (150–180 g) rats. Common bile duct ligation was made after 4 days from bilateral adrenalectomy.We have demonstrated that the ploidy of liver parenchymal cells (4c, 4cx2, 8c) significantly increases during 2 days after common bile duct ligation. We have also demonstrated that combined pathologies cause the speeding‐up of mitotic activity, which is explained by stimulating of signal transduction pathways in cholestatic liver in conditions of hormonal disbalance.