Abstract
Benzoic and acetic anhydrides react in aqueous solutions with monoribonucleotides to give exclusively O-acyl derivatives. The order of reactivity with benzoic anhydride is pG, pA, pU, and pC; pG being five times more reactive than pC (pN = nucleoside 5′-phosphate). The relative reactivity of the nucleotides may be a result of 2′-hydroxyl interaction with the base.
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