Abstract
Activin A receptor type 1 (ACVR1) annotated for its involvement in some key signaling pathways is one promising candidate for economic traits. The aim of this study was to analyze its phenotypic effects on cattle growth traits. Four variations including two intronic Indels and two exonic SNPs were detected in 840 cattle from five Chinese cattle breeds by DNA-pool sequencing. Variations g.33008_33024del (rs385690012) and g.41793C>T (rs458497709) were significantly associated with cattle growth traits which were cannon bone circumference (CBC), chest girth (CG), chest depth (CD) (P < 0.05) using reduced animal general linear model. Additionally, the two significant loci of the studied populations were in Hardy-Weinberg equilibrium and had relatively high heterozygosity which was close to 2p*(1 − p). Conclusively, the two variations g.33008_33024del and g.41793C>T can be used as molecular marker for marker-assisted selection in beef cattle breeding.
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