Abstract
Acute toxicity is a step to evaluate the toxicity of a substance. Rutin is one of the flavonoid compounds with a variety of pharmacological effects. The aim of the study is to calculate the lethal dose that affect fifty percent of the mice used in the experiment (LD50). Thirty Swiss albino male and 30 non-pregnant female mice have been divided equally and randomly into 5 treated groups and one control group (n=5) Rutin has been administered with concentrations 5, 2.5.1.25,0.625 and 0.312 g/kg administered as a single dose intraperitoneally (IP) while the control group received 1% DMSO (IP). Animals were observed for any morbidity and mortality for 14 days. After 14 days the animal blood collected for biochemical and hematological analysis then all animals are euthanized for histopathological evaluation. The results showed the LD50 was 1.51 g/kg for male mice while for female mice was1.49 g/kg. No significant changes were observed at dose of 1.25glkg (female) and 0.625, 0.312 glkg (both sexes) in body weight measurements and in biochemical or hematological assays. Moreover no significant histopathological changes were reported compared to control.. It can be concluded that Rutin is practically a non-toxic substance.
Highlights
Compounds that are derived from herbal or natural origin widely take the world interest as a complementary supplement in many diseases [1] Rutin, is one of the flavonol compounds its chemical structure consists of aglycon part that is linked to glycoside moiety [2] a study conducted in 1936 on citrus fruits and listed as one of vitamins [3] Rutin is present in many vegetables, fruits, plant such as Ruta Graveolens, Eucalyptus spp. , Sophora Japonica and buckwheat [4,5]
The aim of this study is to investigate the acute toxicity of Rutin that can kill 50%of treated male and female Swiss albino mice intraperitoneally at different concentrations over 14 days
Male and female Swiss Albino injected as a single dose intraperitoneally at a different concentration, (5 and 2.5 g/kg), of rutin showed high mortality rate (100%)
Summary
Compounds that are derived from herbal or natural origin widely take the world interest as a complementary supplement in many diseases [1] Rutin, is one of the flavonol compounds its chemical structure consists of aglycon part (quercetin) that is linked to glycoside moiety (rhamnose or called rutinose sugar part) [2] a study conducted in 1936 on citrus fruits and listed as one of vitamins ( vitamin P) [3] Rutin is present in many vegetables, fruits, plant such as Ruta Graveolens, Eucalyptus spp. , Sophora Japonica and buckwheat [4,5]. Compounds that are derived from herbal or natural origin widely take the world interest as a complementary supplement in many diseases [1] Rutin, is one of the flavonol compounds its chemical structure consists of aglycon part (quercetin) that is linked to glycoside moiety (rhamnose or called rutinose sugar part) [2] a study conducted in 1936 on citrus fruits and listed as one of vitamins ( vitamin P) [3] Rutin is present in many vegetables, fruits, plant such as Ruta Graveolens, Eucalyptus spp. Rutin has many biological and pharmacological effects such as anti-inflammatory, antioxidant, antiangiogenic [6,7] it has been found effective in many chronic diseases such as Diabetes Mellitus, hypertension, inflammatory bowel syndrome, hyperlipidemia, and Alzheimer's disease[8,9,10,11]. The aim of this study is to investigate the acute toxicity of Rutin that can kill 50%of treated male and female Swiss albino mice intraperitoneally at different concentrations over 14 days
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