The Acute Hemodynamic Effects of Caffeine During Different Body Positions in Normotensive Young Adults

Elena Ioana Iconaru,Magdalena Diaconu,Alina Bisoc,Mariana Ionela Tudor,Camelia Nicolae,Constantin Ciucurel,Luminita Georgescu,Monica Marilena Tantu,Manuela Mihaela Ciucurel,Alina Paunescu,Cristina Plesa

doi:10.37358/rc.20.1.7823

Abstract

The aim of this study was to investigate the acute cardiovascular hemodynamic effects of administration of a fixed dose of 130 mg of caffeine versus placebo in a sample of healthy young adults (N = 32, sex ratio 1/1), who were successively placed in four distinct positions (orthostatic before ingestion, orthostatic, supine and Trendelenburg vertical positions, after ingestion) on a gravitational inversion table. The experimental design was a single-center, parallel-group, double-blind, randomized, placebo-controlled clinical trial. Following the descriptive and inferential statistical processing of the data, a statistical significant pattern (p [0.05) of acute postural cardiovascular hemodynamic adaptation of the subjects was revealed, under the influence of caffeine versus placebo ingestion.

Highlights

The aim of this study was to investigate the acute cardiovascular hemodynamic effects of administration of a fixed dose of 130 mg of caffeine versus placebo in a sample of healthy young adults (N = 32, sex ratio 1/1), who were successively placed in four distinct positions on a gravitational inversion table
Experimental part This study aimed to investigate the acute hemodynamic effects of caffeine intake versus placebo in a sample of 32 volunteers, healthy young adults, who were successively placed in distinct positions
As for diastolic BP (DBP) (Fig. 3), we found a significant main effect for Group, F (1, 15) = 5.174, p = 0.038, Eta-squared = 0.256, for Postures, F (1.548, 23.216) = 18.436, p < 0.001, Eta-squared = 0.551, and for interaction Group x Postures F (3, 45) = 9.764, p < 0.001, Eta-squared = 0.394

Summary

Introduction

The aim of this study was to investigate the acute cardiovascular hemodynamic effects of administration of a fixed dose of 130 mg of caffeine versus placebo in a sample of healthy young adults (N = 32, sex ratio 1/1), who were successively placed in four distinct positions (orthostatic before ingestion, orthostatic, supine and Trendelenburg vertical positions, after ingestion) on a gravitational inversion table. Coffee consumption increases central BP and peripheral diastolic BP, but does not significantly affect the peripheral systolic BP [9] It seems that data concerning acute BP changes, after caffeine consumption, are contradictory especially in healthy young subjects [9]. Knowing that during the occupational activities the human body can be placed in different positions, it becomes attractive to study in this context the effects of the administration of a usual dose of caffeine on the cardiovascular parameters. In daily life, caffeine intake in people adopting occupational positions is frequent

Objectives

Results

Conclusion