Abstract
AbstractThe acute effects of single oral doses of antidepressants, maprotiline and amoxapine on serum levels of prolactin (PRL), luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) were studied in six normally cycling women. After oral administration of 25 mg maprotiline, no significant increase was observed in serum PRL levels, but PRL levels increased significantly (p<0.05) 6 hour after administration of 25 mg amoxapine. There were no significant changes in serum LH and FSH levels after taking either drug. These results suggest that amoxapine increases PRL levels and possibly leads to galactorrhea and amenorrhea. It is recommended to use antidepressants that do not cause hyperprolactinemia, e.g. maprotiline, especially in female patients.
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