Abstract
Rats in water diuresis were given intravenous injections of vasopressin, or of isotonic NaCl for controls. Serial urine sampling showed that maximal osmolality and minimal flow were achieved half an hour after vasopressin injection, and that urea excretion was low at this time. In animals killed half an hour after injection, the composition of the renal papilla, medulla and cortex was studied.The urea and ammonium concentration and content increased in the inner medulla after vasopressin injection, and the water content increased in all the kidney slices, but significantly so only in the papilla. The medullary osmolality did not alter appreciably, the accumulation of urea and ammonium being counter‐balanced by the increase of water. The urine osmolality did not reach the level found in the medulla. No appreciable change of sodium or potassium concentration or content of kidney slices was observed after vasopressin injection. The results are discussed in relation to means whereby vasopressin induces antidiuresis and urinary hypertonicity.
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