The actual condition of laboratory diagnostic of Clostridium difficile-associated diarrhea; the methods of detection of toxigenic strains (review of publications).

Abstract

The Clostridium difficile-associated infection (CDI) is one of the main causes of nosocomial diarrhea. The complicacy of laboratory diagnostic results in progression of disease bringing on extensive inflammatory alterations in the wall of large intestine and characterizing by superficial necrosis of mucous membrane with development of "pseudo-membranes" resulting in development of toxic megacolon, perforation of intestinal wall, peritonitis and sepsis. The main role in diagnosing plays indication of agent and detection of its toxins. None of laboratory tests can be applied as an independent technique of laboratory diagnostic of CDI. The multi-step diagnostic can become an appropriate strategy for quick and full detection of antibiotic-associated diarrhea.