Abstract
Soluble fractions were prepared in parallel from normal and regenerating rat livers, and their capacity to activate amino acids for incorporation into proteins by liver microsomes was determined in incorporation systems using 14C- l-leucine. When the relative activities of the supernatant fractions were compared at different periods after partial hepatectomy, a rise was observed after a lag period of about 12–14 hours. The rise was apparently about simultaneous with the rapid increase in microsomal activity, which occurs at the beginning of the regeneration period. The increased activity of the soluble fraction, however, was quantitatively less pronounced than the activation of the microsomal material. The activity of the soluble fractions culminated on the second day after the hepatectomy. The rise was not primarily due to a higher efficiency of the ATP-generating system, but mainly to increased activities of the amino acid activating enzymes.
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