Abstract
BackgroundThe expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI).MethodsThe atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. The atherothrombotic plaques were obtained by aspiration thrombectomy during percutaneous coronary intervention within 12 hours from the onset of symptoms and prepared for IHC analysis.ResultsIn the IHC analysis staining for PAPP-A occurred in the extracellular matrix of the plaques and no evidence of staining for PAPP-A was found in the thrombi.ConclusionOur results indicate that in vivo PAPP-A is strongly expressed in atherothrombotic plaques harvested from patients admitted with STEMI, as documented by IHC.Trial registrationbiobankregisteret@fhi.no1846
Highlights
The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI)
Pregnancy-associated plasma protein A (PAPP-A) is a zinc-binding matrix metalloproteinase that can be detected in the blood of patients with acute coronary syndromes (ACS) [1,2]
In a prior study we have assessed the immediate effects of coronary reperfusion procedures on the plasma concentrations of PAPP-A in patients admitted with ACS and ST-elevation myocardial infarction (STEMI) [3]
Summary
The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI). Existing data does not allow us to define the exact role of PAPP-A in plaque disruption. This metalloproteinase has been shown in earlier studies to be expressed in ruptured plaques, these results were limited by the fact that the histological samples were collected postmortem [1]. We wanted to identify the expression of PAPP-A by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with STEMI
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