Abstract
Interleukin-11 (IL-11) is a unique cytokine and growth factor with numerous immunologic and trophic effects that affect multiple cell lines. Among its most favorable attributes is its physiologic activity in the maintenance of gastrointestinal epithelial integrity after mucosal injury. This multifunctional cytokine may prove beneficial in a variety of pathologic states in clinical medicine. Recombinant human interleukin-11 is beneficial in the prevention and treatment of mucosal injury in experimental models of immunologic, cytotoxic, ischemic, and oxidant injury. In addition, IL-11 has growth potential activity for enterocytes and is beneficial in short bowel syndrome after massive intestinal resections in animals; IL-11 also prevents mucosal ulceration, enterocyte apoptosis, and gut translocation of bacterial endotoxin and enteric pathogens after irradiation or cytoreductive chemotherapy. Interleukin-11 may provide a much-needed treatment strategy to preserve the gastrointestinal epithelium in critically ill patients.
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