Abstract
N-Formimidoyl thienamycin is a new β-lactam antibiotic which is active against Pseudomonas aeruginosa. This activity is neither significantly influenced by variations in inoculum density nor by changes in pH. Gentamicin, however, although it does not exhibit an inoculum effect, does lose activity with decreases in pH. It is argued that in order for a rational selection of antibiotics to be made on the basis of in-vitro activity, that the in-vitro system should simulate the in-vivo situation as closely as possible. This should take into account such variables as population densities and local tissue pH as well as cation content.
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