Abstract
Abstract Objectives Obesity has become an important public health problem because of its increasing prevalence and relation with many diseases and mortality. Studies have shown its association with oxidative stress. In this study, the effect of obesity on total amount of thiol and some glutathione S-transferase (GST) isozymes were investigated which could serve as an important criteria in dose adjustment of some certain drugs in obese. Methods The gastric tissues removed by gastrectomy operation from 29 morbid obese female patients were analysed for thiol levels and activities of total GST, GSTT1-1 and GSTM1-1. Patients were grouped according to age, presence of hypertension and/or diabetes, and family history. Results The average total thiol was 131.22 (±7.74) nmol/mg protein with no significant differences in between the groups. GSTT1 specific activities were about 20% higher in four groups: with ages over 35 years old, with hypertension, without diabetes and finally without family history, with respect to other groups. The differences between total GST and GSTM1 activity levels of experimental groups were not significant. Conclusions This is the first study to compare activities of GST isozymes and total thiol content in the stomach tissues of obese female patients accompanying some common metabolic disorders, age and family history.
Highlights
Obesity is a risk factor or determinant for a number of chronic diseases such as diabetes, cardiovascular morbidity and cancer
Only 3% difference was observed between the total glutathione S-transferase (GST) specific activities measured in the stomach tissues of patients grouped according to age criteria
While no significant difference was observed for GSTM1 isozyme activity, it was determined that the average of total amount of thiol for the group above 35 years of age was 3% higher than the group of 35 years old and younger, in contrast to the trend observed in total GST activity
Summary
Obesity is a risk factor or determinant for a number of chronic diseases such as diabetes, cardiovascular morbidity and cancer. Over the past 50 years, worldwide prevalence of obesity has nearly tripled and it continues to grow at a pandemic dimension. Obesity is widespread in Turkey compared to most other countries and its prevalence is higher, especially, among women. When the percentages of obesity among female, male and for overall Turkish population in 2011 were compared with those of 2017, there were elevations from 58 to 66% for women, from 52.7 to 62.8% for men, and from 55.4 to 64.4% for whole population [2]. Obesity is a growing problem for Turkey
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