Abstract
Abstract A pithed rat preparation, stimulated electrically via the pithing rod left in position, was employed to examine the effects of drugs, administered intravenously, on relaxation of a loop of ileum. Relaxation due to injected isoprenaline could be largely blocked by propranolol but that due to nervous stimulation or injected noradrenaline was blocked to only a lesser extent by either propranolol or phenoxybenzamine alone. The combination of phenoxy-benzamine and propranolol was more effective against relaxation from nervous stimulation than either drug alone but was still not as effective against this as against noradrenaline, or as propranolol alone against isoprenaline. It is concluded that intestinal relaxation after nervous stimulation involves both α- and β-adrenergic activity, in variable proportions. Adrenoceptive antagonists are not as effective in blocking these receptors as they are for those concerned in relaxation after injected catecholamines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
