The active site of human Tyrosinase-related Protein: can it be inhibited by plants?

Abstract

Tyrosinase and tyrosinase-related proteins (TYRPs) play an important role in melanogenesis. TYRPs present in the membrane of melanosome, are known to function in the activation and stabilization of tyrosinase, melanosome synthesis, increase eumelanin/pheomelanin ratio, and in reducing oxidative stress due to its peroxidase effect. Besides, the tyrosinase enzyme is the main enzyme that catalyzes the rate of melanin synthesis, whereas the downregulation of tyrosinase is the most prominent way of d