Abstract

The effects of tryptamine on serum insulin levels were investigated. Tryptamine induced an apparent increase in serum insulin levels in mice. The elevation in insulin elicited by tryptamine was potently antagonized by the 5-HT 1 and 5-HT 2 receptor antagonist, methysergide, but partially reduced by the 5-HT 2 receptor antagonsit, ketanserin. However, the 5-HT 3 receptor antagonist, ICS 205–930, was without effect. These results indicate that both 5-HT 1 and 5-HT 2 receptors are involved in the tryptamine-induced increase in insulin levels.

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