Abstract
Activated oncogene c-Ha-ras in stomach cancer tissues was identified by DNA transfection. The point mutations were determined in five DNA samples (from three solid tumors of patients with gastro carcinoma and two cell lines) out of twelve (eight solid tumors and four cell lines) by the restriction fragment length polymorphysm (RFLP) assay. The expressions of c-Ha-ras were enhanced to higher levels (10–20 times) in two cell lines. The lengths of variable tandem repetition (VTR) sequences downstream from the c-Ha-ras coding region were compared for different DNA samples. Their ability to enhance c-Ha-ras expression and their transforming ability are discussed.
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