Abstract
Abstract Several non-steroidal acidic anti-inflammatory drugs had a lytic action on lysosomes at high concentrations but no apparant action at lower concentrations. The drugs also inhibited acid phosphatase activity but only at high concentrations. High concentrations of drugs accelerated the thermal denaturation of albumin solutions but partially protected the albumin against denaturation at lower concentrations. The possibility that the denaturing action of drugs on proteins at high concentrations is related to lysosomal damage and that this damage may be associated with ulceration in vivo is discussed. Salicylate was found to inhibit the stabilizing action of cortisol on lysosomes.
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