Abstract
Sildenafil (Viagra) has proved useful for alleviating fetal growth restriction, but we have found that it has direct effects on trophoblast invasion and survival during oxidative stress. However, the mechanism is not completely understood. Heparin-binding EGF-like growth factor (HBEGF) has similar effects on human trophoblast cells. Therefore, we examined whether there is a link between sildenafil and HBEGF signaling.
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