The actions of 2-hydroxy-saclofen at presynaptic GABA B receptors in the rat hippocampus

Abstract

The actions of 2-hydroxy-saclofen (2-OH-S), a recently develoepd analog of baclofen, were studied at presynaptic GABA B receptors in the rat hippocampal slice. Baclofen (0.5–20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200–500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABA B receptors on excitatory terminals in the hippocampus.