Abstract
Perezone (2-(1,5-dimethyl-4-hexenyl)-3-hydroxymethyl- p-benzoquinone) is a sesquiterpenic benzoquinone isolated from roots of plants of the genus Perezia. It exhibits oxido-reduction characteristics which suggest that the compound can be used for studies of the electron transfer chain of rat liver mitochondria. Perezone at 50 μ m inhibits mitochondrial electron transport through a process which differs from that of rotenone, amytal, and Antimycin A. The inhibition is temperature dependent; at 35 °C it fails to inhibit valinomycin-induced mitochondrial respiration, but at 20 °C it inhibits respiration by 80–90%. Perezone is an electron-donor and electron-acceptor compound that behaves similarly to naphtoquinone. It mediates electron transport from a reaction center preparation isolated from Rhodopseudomonas sphaeroides and added cytochome c. The low respiration of rat liver mitochondria depleted of coenzyme Q 10 (CoQ) is increased by perezone. The electron transport activity of perezone was also demonstrated with CoQ-deficient yeast mutant E3-24.
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