Abstract
Recombinant bovine interferon-α and -γ differ in their action against influenza virus on bovine cells. Bovine IFN-α severely impairs early protein synthesis and replication of influenza virus in bovine cells in contrast to bovine IFN-γ which fails to induce an antiviral state against influenza virus. Otherwise the IFN system seems to function normally in bovine cells since both bovine IFN-α and -γ induce an antiviral state against vesicular stomatitis virus. The establishment of the specific antiviral state against influenza virus correlates with the induction by bovine IFN- a, but not γ, of two cytoplasmic proteins related to the IFN-induced mouse protein Mx involved in the mechanism of resistance of mice to influenza virus infection. This study suggests that bovines possess a system for resistance to influenza virus similar to the mouse Mx system.
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