The action of prostaglandin E 2 and F 1α on myocardial ischaemia-infarction arrhythmias in the dog

Abstract

Prostaglandin E 2 and F 1α infusions have been tested for their ability to reduce the arrhythmias associated with occlusion of the left descending coronary artery in the anaesthetised dog. At 1 μg/kg/min both PGs reduced the incidence of premature ventricular contractions occurring during 25-min occlusions, while not reducing the incidence of ventricular fibrillation occurring on occlusion release. When infused for 5-min periods at 1 to 16 μg/kg/min, neither PGE 2 nor PGF 1α effectively reduced the frequency of ventricular arrhythmias occurring 24 hr after a permanent coronary occlusion.