Abstract
The low-weight aromatic hydrocarbons benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX), are among the most common hazardous sources of environmental contamination. The present review is the first summarization the data obtained during epidemiological, animals and cell culture studies concerning BTEX action on different aspects of male reproductiontesticular cell apoptosis, spermatogenesis, cytogenetics, pituitary and peripheral hormones and intracellular signaling systems. Analysis of the available literature demonstrates that BTEX can exert hazardous effects on various reproductive sites, including the pituitary-gonadal axis, hormone receptors and intracellular signaling molecules, testicular cell apoptosis, spermatogenesis and fertility. There are indications, that BTEX reproductive effects could be due to the ability of BTEX to affect embryonal gonads, to induce testicular cell mutagenesis and destroy chromosomes, to promote accumulation of free radicals, to affect hormones and hormonal receptors, cell cycle and CNS structures regulating reproduction, but only the role of free radicals in mediating BTEX action on male reproduction has been proven by experiments yet. Some approaches to prevent negative action of BTEX are outlined.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Austin Journal of Reproductive Medicine & Infertility
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
