Abstract
The electrical activity of single pyramidal cells in the hippocampus was monitored extracellularly during electrical stimulation of nucleus locus coeruleus (LC) in anesthetized rats. Stimulation of the LC produced long-lasting inhibition of spontaneous activity of pyramidal cells. This inhibition was reversibly blocked during iontophoretic administration of MJ-1999, a beta adrenergic blocking agent, potentiated during administration of DMI and was absent in 6-OHDA treated rats. The inhibition was not apparently mediated by extraneuronal mechanisms nor by a GABA containing synapse. It was potentiated by papaverine and antagonized by prostaglandin E 1, substances which affect cAMP metabolism. It is suggested that the inhibitory synapses of the fibers from LC to the hippocampus utilize NE as a transmitter.
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