Abstract
The paper gives a brief review of the literature data based on in vitro investigations of cytotoxic action of cisplatin and irradiation, applied alone or in combination, to carcinoma cell lines and fresh tumor explants. Presented data, observed in the light of data obtained in clinics, indicate that in vivo some additional tumor destructive activity might be induced by applied therapy. Therefore examinations of the antitumor effect of some treatment need to be more complex and must include determination of the effects of applied therapy on set of parameters, which control tumor growth in vivo.
Highlights
The aim to enhance the antitumor effect led many physicians to design various combined treatment modalities
Several publications reported that cytotoxic effect of combined treatment is lower than treatments when radiotherapy or chemotherapy was applied alone
The results suggest that caution is needed in medical application of radiation combined with chemical treatment
Summary
The aim to enhance the antitumor effect led many physicians to design various combined treatment modalities. Cis-diamminedichloroplatinum (cis-DDP, cisplatin), inducing tumor cell death mainly trough interaction with intrastrand DNA bases, has shown its powerful antitumor activity to various types of tumors, [2,3] both in vitro and in vivo. Combination of these two treatment modalities aimed to enhance local tumor control, relapse free survival and overall survival. It must be mentioned that occasional absence of benefit of combined therapy of heavy advanced disease has been reported too [9,10] Examinations of the antitumor effect of some treatment need to be more complex and must include determination of the effects of applied therapy on set of parameters, which control tumor growth in vivo
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