Abstract
The effect of intramuscular histidine on gastric secretion was studied in dogs with accessory stomachs and in gastrostomized preparations. In vitro experiments were performed to determine the action of this amino acid on intestinal tone and motility. Histidine did not decrease the volume or acidity of gastric secretory response to either food or histamine stimulation. In two of three pouch dogs and in one of two gastrostomized dogs there occurred a prolonged and increased secretory response coincident with histidine administration. In organ baths, histidine in physiological concentrations had no effect on the tone or motility of segments of small intestine. The data presented in the above experiments offer no support for the therapeutic claims made for histidine in the treatment of peptic ulcer in man.
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