Abstract
Immediately following short periods of vigorous muscular work, there is a marked reduction in the bicarbonate content of the blood, a phenomenon observed by Christianson, Douglass and Haldane in 1914.1 The initial purpose of the present investigation has been to discover what changes in the reaction and the CO2 tension of arterial blood accompany the diminution in bicarbonate. For this purpose, four individuals without demonstrable organic defects but of varying grades of apparent fitness were selected for experiment. Each did on a Krogh bicycle ergometer a standard amount of exercise which consisted of the performance of approximately 3,500 kilogrammeters of work in three and a half minutes. The method employed upon the blood is that introduced by Henderson and Haggard2 and consists in the simultaneous determination of the carbon dioxide absorption curve of blood at body temperature and the carbon dioxide content of the arterial blood as it occurs in the body. The reaction of the arterial blood is calcul...
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