Abstract
The most direct conceivable route for synthesis of multicarbon compounds from CO 2 is to join two molecules of CO 2 together to make a 2-carbon compound and then polymerize the 2-carbon compound or add CO 2 successively to the 2-carbon compound to make multicarbon compounds. Recently, it has been demonstrated that the bacterium, Clostridium thermoaceticum, grows autotrophically by such a process. The mechanism involves the reduction of one molecule of CO 2 to a methyl group and then its combination with a second molecule of CO 2 and CoA to form acetyl-CoA. We have designated this autotrophic pathway the acetyl-CoA pathway [1]. Evidence is accumulating that this pathway is utilized by other bacteria that grow with CO 2 and H 2 as the source of carbon and energy. This group includes bacteria which, like C. thermoaceticum, produce acetate as a major end product and are called acetogens or acetogenic bacteria. It also includes the methane-producing bacteria and sulfate-reducing bacteria. The purpose of this review is to examine critically the evidence that the acetyl-CoA pathway occurs in other bacteria by a mechanism that is the same or similar to that found in C. thermoaceticum. For this purpose, the mechanism of the acetyl-CoA pathway, as found in C. thermoaceticum, is described and hypothetical mechanisms for other organisms are presented based on the acetyl-CoA pathway of C. thermoaceticum. The available data have been reviewed to determine if the hypothetical schemes are in accord with presently known facts. We conclude that the formation of acetyl-CoA by other acetogens, the methanogens and sulphate-reducing bacteria occurs by a mechanism very similar to that of C. thermoaceticum.
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