Abstract
Acetylcholinesterase (AChE), encoded by the Ace gene, is the primary target of organophosphorous (OP) and carbamate insecticides. OP resistance has developed via a range of mechanisms in insect many species. Ace mutations have been identified in OP resistant strains of Drosophila melanogaster 1. However, in the Australian sheep blowfly, Lucilia cuprina, resistance in field strains and laboratory generated mutants is determined by point mutations in the Rop-1 gene2,3, which encodes a carboxylesterase, E34. To investigate the apparent bias for the Rop-1 /E3 mechanism in the evolution of OP resistance in L. cuprina, we have sequenced the Ace gene from this species (Genbank Accession U88631). Alignment of the L. cuprina and D. melanogaster sequences demonstrates 83.9% identity at the amino acid level and 67.3% identity at the nucleotide level.
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