Abstract
The Acetobacteraceae: Extending the Spectrum of Human Pathogens
Highlights
Patients with chronic granulomatous disease (CGD) get recurrent infections with a variety of bacterial and fungal pathogens as a consequence of phagocyte defects in production of antimicrobial reactive oxygen metabolites
In this issue of PLoS Pathogens, David Greenberg, Steven Holland, and colleagues [1] have isolated and characterized a new bacterium, Granulobacter bethesdensis, from the lymph nodes of a patient with CGD and recurrent idiopathic lymphadenitis. They have shown that G. bethesdensis represents a new genus and species in the Acetobacteraceae family
The 16S rRNA gene sequence of the bacterium reisolated from infected mouse tissues was identical to the sequence from the bacterium originally isolated from the patient
Summary
Patients with chronic granulomatous disease (CGD) get recurrent infections with a variety of bacterial and fungal pathogens as a consequence of phagocyte defects in production of antimicrobial reactive oxygen metabolites. In this issue of PLoS Pathogens, David Greenberg, Steven Holland, and colleagues [1] have isolated and characterized a new bacterium, Granulobacter bethesdensis, from the lymph nodes of a patient with CGD and recurrent idiopathic lymphadenitis. The bacterium was repeatedly isolated in charcoal–yeast extract medium from several lymph nodes of the patient over several months.
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