Abstract
The accumulation of C 14-hypoxanthine by slices of rabbit kidney cortex has been examined. The label was taken up over a long time course and reached steady state levels only after 4 hr. No evidence was found of metabolic transformation of the labeled material indicating that the slow accumulation is a characteristic of the transport process. The uptake of 14C-hypoxanthine was depressed by metabolic inhibitors (dinitrophenol, cyanide, iodoacetamide). Of the substrates tested, only acetate stimulated uptake, while succinate, α-ketoglutarate, pyruvate, and citrate depressed uptake. Substances which affect the organic acid transport system (bromcresol green and probenecid) were without effect. Tetraethylammonium chloride and quinine, both of which are transported by the organic base system, significantly depressed 14C-hypoxanthine uptake.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
