Abstract
1. The lateral and fourth ventricular choroid plexuses of the rabbit have been shown to be capable of the in vitro accumulation of 5-hydroxyindol-3-ylacetic acid (5-HIAA).2. The accumulation of 5-HIAA occurs against a concentration gradient and is dependent on metabolic energy.3. It is possible to inhibit the accumulation of 5-HIAA by the presence of the dopamine metabolite, 3-methoxy-4-hydroxyphenylacetic acid (HVA) or of probenecid in the incubation medium.4. It would appear that the characteristics of the accumulation of 5-HIAA by the isolated choroid plexuses are consistent with the involvement of this tissue in the in vivo active transfer of 5-HIAA from the c.s.f. to the blood.
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