The accessory optic system of the rabbit, cat, dog and monkey: a whole-mount HRP study

Abstract

The three-dimensional fiber pathways of the accessory optic system in the rabbit, cat, dog and monkey were studied in whole-mounted preparations of the diencephalon and the midbrain, without sectioning, by anterograde labeling of retinal axons with horseradish peroxidase (HRP). HRP histochemical studies on alternate serial coronal sections were also performed. The rabbit accessory optic system exhibited two fasciculi (the inferior fasciculus, and the superior fasciculus consisting of the anterior fibers and the posterior fibers) and three terminal nuclei (the medial terminal nucleus, and the anterior and posterior portions of the lateral terminal nucleus), but lacked the dorsal terminal nucleus. In the cat and dog, only the posterior fibers of the superior fasciculus were detected. The inferior fasciculus and the anterior fibers of the superior fasciculus were absent. The medial terminal nucleus and the posterior portion of the lateral terminal nucleus were commonly observed in the cat and dog. The cat accessory optic system possessed the dorsal terminal nucleus, and the dog accessory optic system possessed the anterior portion of the lateral terminal nucleus. The monkey (Macaca fuscata) accessory optic system consisted of the posterior fibers of the superior fasciculus, but blacked the inferior fasciculus and the anterior fibers of the superior fasciculus. Most of the posterior fibers terminated in the well-developed posterior portion of the lateral terminal nucleus located on the upper surface of the cerebral peduncle. A small number of posterior fibers projected to the poorly-developed medial terminal nucleus. Based on these findings, species differences in the mammalian accessory optic system were discussed.