Abstract
Abstract The absorption of quinine and chlorpheniramine with anionic agents was examined in the rat rectum, small intestine and stomach. The enhancement of absorption was related to partition behaviour, to the organic solvent, and surface activity of ion-pair complexes, but it seems that with results from these properties alone it is not possible to explain the apparent increase in the in situ absorption of amines. In the presence of anionic agents, the absorption of amines was enhanced at all sites examined and kinetically the uptake to the mucosal membrane was increased in the rectum and small intestine. The effect of anionic agents on the uptake of amines was greater in the rectum than in the small intestine and this may be related to differences in the nature of the gut wall.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
