Abstract
The chiral aminoalkylphenol N-[(S)-1-(5-methyl-2-hydroxyphenyl)ethyl]-N–[(R)-2-hydroxy-1-phenylethyl]amine, C17H21NO2, was synthesized starting from R-(-)-2-phenylglycine. The corresponding hydrochloride salt was prepared and crystallized as an ethyl acetate solvate, affording N-[(R)-2-hydroxy-1-phenylethyl]-N-[(S)-1-(5-methyl-2-hydroxyphenyl)ethyl]aminium chloride ethyl acetate solvate, C17H22NO2 +·Cl−·C4H8O2, and the absolute configuration of the new stereogenic centre determined, from which that of the chiral aminoalkylphenol was inferred. The dihedral angle between the two aromatic rings is 40.74 (11)°.
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