The abnormal bifid W-waveform visual evoked potential early indicated of demyelination optic neuritis is a primary sign of multiple sclerosis disease

Abstract

Objective: Multiple sclerosis (MS) is the inflammatory demyelinating process resulting in the episodic neurological dysfunction, involvement of the retinal pathway in the form of optic neuritis. These are clinical causes of ophthalmic symptoms, such as the blurring of vision, impaired of vision, and some cases are silent and the visual evoked potential (VEP) may be beneficial if there is abnormality along the optic tract.Methods: A total of 20 elected patients with MS compared with 15 healthy control groups. All groups in the present study conducted by the reversal pattern of VEP test for both eyes identify the N75-P100-N145 parameters and the percentage of the bifid W-waveform recorded in VEP.Results: The VEPs study recorded the highly significant difference in comparing between the patients and the control group; we found the significant difference (<0.005) in latency of N75, P100, N145 and N75/P100 amplitude in both eyes. The bifid W-waveform of abnormal VEP recorded in 65% of patients, 45% of the patients had bifid changes in both eyes and 20% of patients had changes in the left eye. These changes of waveform ship had a significant relationship to loss of amplitude but not related to prolong of P100 latency.Conclusion: The bifid W-shape waveform in abnormal VEP indication in early diagnosis the demyelination lesions of the optic pathway in patients with clinical and subclinical ophthalmic manifestation, a primary sign of MS diseases.